The Influence of Thyroidectomy, Splenectomy, Gonadectomy, and Suprarenalectomy upon the Development of Experimental Atherosclerosis in Rabbits
نویسنده
چکیده
Alimentary hypercholesterolemia acting over a sufficient period of time (in rabbits with all organs intact, 110 days or longer) causes deposition of cholesterol within the intima of the aorta. Deposition of cholesterol within the intima of the aorta initiates the formation of experimental atheromata. Thyroidectomy, splenectomy, and gonadectomy augment hypercholesterolemia and thereby facilitate and accelerate the development of experimental atheromata of the aorta in rabbits. Sublethal suprarenal insufficiency does not increase the susceptibility of rabbits to the development of such atheromata.
منابع مشابه
The Influence of Thyroidectomy, Gonadectomy, Suprarenalectomy, and Splenectomy on the Thymus Gland of Rabbits
Thyroidectomy hastens, while gonadectomy delays, but does not permanently prevent, involution of the thymus. Suprarenalectomy alone not only delays involution of the thymus and lymphoid tissue but may cause their regeneration. Thyroidectomy prevents this reaction even after combined suprarenalectomy and gonadectomy. Suprarenalectomy plus gonadectomy is a more powerful stimulus for thymus and ly...
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 45 شماره
صفحات -
تاریخ انتشار 2003